Mouse embryonic stem cells (ESCs) and epiblast-derived stem cells (EpiSCs) represent the initial naive and final primed phases of pluripotency, respectively. Electronic address: cells emerge as a naive founder population in the blastocyst, acquire capacity for germline and soma formation, and then undergo lineage priming. ![]() 6 Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK Living Systems Institute, University of Exeter, Exeter EX4 4QD, UK. ![]() 5 Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK. ![]()
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